abstract：:Mitochondrial DNA 5178 adenine/cytosine (mt5178 A/C) polymorphism is reportedly associated with longevity and susceptibility to age-related diseases in Japanese individuals. We previously reported an association between mt5178 A/C polymorphism and serum protein fraction levels in healthy Japanese women. An association...

journal_title：Mechanisms of ageing and development

authors： Kokaze A,Ishikawa M,Matsunaga N,Yoshida M,Sekine Y,Sekiguchi K,Satoh M,Harada M,Teruya K,Takeda N,Uchida Y,Takashima Y

更新日期：2003-06-01 00:00:00

abstract：:It has been shown that enhanced levels of p53 activity contribute to reduced cancer susceptibility in mice, however longevity is compromised due to the onset of an early-ageing phenotype. The effects of enhanced levels of p53 in these in mice could therefore have implications for human premature ageing disorders. We e...

journal_title：Mechanisms of ageing and development

authors： O'Neill M,Núñez F,Melton DW

更新日期：2003-05-01 00:00:00

abstract：:Apoptosis plays a central role in the homeostasis of the immune system. During aging, there is an altered regulation of pivotal molecules that are responsible for the regulation of this type of cell death, such as those of the Fas/FasL system. Understanding the regulation of these genes can help to clarify, at least i...

journal_title：Mechanisms of ageing and development

authors： Pinti M,Troiano L,Nasi M,Monterastelli E,Moretti L,Bellodi C,Mazzacani A,Mussi C,Salvioli G,Cossarizza A

更新日期：2003-04-01 00:00:00

abstract：:In this paper, we presented the results of analysis of experimental evidence for the decline of the human immune system functioning with age using mathematical model of immunosenescence. The most prominent changes in this system are related to the decline in the T-cellular immunity. These include the decline in the na...

journal_title：Mechanisms of ageing and development

authors： Romanyukha AA,Yashin AI

更新日期：2003-04-01 00:00:00

abstract：:Age-specific incidence rates for cancers of the female breast, ovary, corpus uteri, testis, prostate and male and female cancers of the stomach, colon, rectum, lung, and male and female Hodgkin's disease in 51 worldwide populations in the 1990 era were obtained from a published source. For each cancer in each populati...

journal_title：Mechanisms of ageing and development

authors： Dix D

更新日期：2003-03-01 00:00:00

abstract：:The release of cytokines is of crucial importance in the regulation of the type and magnitude of the immune response in the elderly. A number of studies have shown different levels of cytokine production in the elderly. In the present study, a range of polymorphisms were chosen within the genes of cytokines (IL-2, IL-...

journal_title：Mechanisms of ageing and development

authors： Ross OA,Curran MD,Meenagh A,Williams F,Barnett YA,Middleton D,Rea IM

更新日期：2003-02-01 00:00:00

abstract：:Considerable evidence points to an accumulation of somatic mutations in older cells and organisms but the causal role of mutations in the ageing process is still unclear. In addition to demonstrating that mutations accumulate, it is important to address the question of whether they do so at a sufficient rate and with ...

journal_title：Mechanisms of ageing and development

authors： Kirkwood TB,Proctor CJ

更新日期：2003-01-01 00:00:00

abstract：:Ageing is the most complex phenotype currently known, since it becomes manifest in all organs and tissues, affects an organism's entire physiology, impacts function at all levels and increases susceptibility to all major chronic diseases. Insight into the molecular and cellular targets of the ageing process would offe...

journal_title：Mechanisms of ageing and development

authors： Vijg J,Suh Y

更新日期：2003-01-01 00:00:00

abstract：:Amyloidosis refers to a group of protein folding diseases. Various innocuous and soluble proteins in physiological conditions polymerize to insoluble amyloid fibrils in several serious diseases, including Alzheimer's disease (AD) and prion diseases. In addition, senile amyloidosis is a form of amyloidosis in which the...

journal_title：Mechanisms of ageing and development

authors： Xing Y,Higuchi K

更新日期：2002-11-01 00:00:00

abstract：:In this investigation the effect of 4 months of 40% restriction of calories on defined markers of oxidative, glycoxidative or lipoxidative damage to heart mitochondrial proteins was studied. The protein markers assessed were N(epsilon)-(carboxyethyl)lysine (CEL), N(epsilon)-(carboxymethyl)lysine (CML), N(epsilon)-(mal...

journal_title：Mechanisms of ageing and development

authors： Pamplona R,Portero-Otín M,Requena J,Gredilla R,Barja G

更新日期：2002-09-01 00:00:00

abstract：:Food restriction (FR) may increase longevity by increasing the efficiency of energy utilization by some organs. We tested whether any effect of FR on the energy efficiency of isolated, isovolumically beating hearts could be observed, by studying four groups of rats: (1). AL fed (AL) 10-13-month-old rats, (2). age matc...

journal_title：Mechanisms of ageing and development

authors： Klebanov S,Herlihy JT,Freeman GL

更新日期：2002-07-01 00:00:00

abstract：:A significant positive correlation between bone mineral density (BMD) and serum dehydroepiandrosterone sulfate (DHEA-S) was found in 120 postmenopausal women (51-99 years old) but no correlation was seen between BMD and serum estradiol. In subset analysis, strong positive correlation of serum DHEA-S and estrone with B...

journal_title：Mechanisms of ageing and development

authors： Takayanagi R,Goto K,Suzuki S,Tanaka S,Shimoda S,Nawata H

更新日期：2002-04-30 00:00:00

abstract：:Cellular and organismal decline is, in part, believed to be a consequence of oxygen and nitrogen-based reactants which persistently damage macromolecules throughout a lifetime. The resulting accumulation of damaged molecules eventually seriously compromises essential functions of cells leading to their death. Excessiv...

journal_title：Mechanisms of ageing and development

authors： Reiter RJ,Tan DX,Burkhardt S

更新日期：2002-04-30 00:00:00

abstract：:The functional deterioration of an organism with age causes the major problem of maintaining the quality of life at old age. Degenerative changes in the organism may to some extent reflect alterations that can be observed in cells during in vitro replicative senescence. At the cellular level, the receptor-mediated end...

journal_title：Mechanisms of ageing and development

authors： Park SC

更新日期：2002-04-30 00:00:00

abstract：:The growing proportion of older people, especially the very old, is often thought of in negative terms such as the need for more health care. But the implications are wider and affect the future of family care as well as issues of intergenerational relations, employment, living arrangements and attitudes. This paper l...

journal_title：Mechanisms of ageing and development

authors： Tinker A

更新日期：2002-04-01 00:00:00

abstract：:Thymic atrophy or thymus absence causes depressed thyroid-thymus axis (TTA) efficiency in old, young propyl-thiouracil (PTU) (experimental hypothyroidism) and in young-adult thymectomised (Tx) mice, respectively. Altered zinc turnover may be also involved in depressed TTA efficiency. Zinc turnover is under the control...

journal_title：Mechanisms of ageing and development

authors： Mocchegiani E,Giacconi R,Cipriano C,Gasparini N,Orlando F,Stecconi R,Muzzioli M,Isani G,Carpenè E

更新日期：2002-03-31 00:00:00

abstract：:Hypertension is a main risk factor for cerebrovascular disease, including vascular dementia. The present study was designed to evaluate if hypertension-dependent changes of the hippocampus of spontaneously hypertensive rats (SHR) of different ages were related with those occurring in vascular dementia. The hippocampus...

journal_title：Mechanisms of ageing and development

authors： Sabbatini M,Catalani A,Consoli C,Marletta N,Tomassoni D,Avola R

更新日期：2002-03-15 00:00:00

abstract：:Expression of dystrophin and the dystrophin-related protein utrophin has been studied in the human fetal brain both in vivo and in vitro. Results showed that both these proteins were developmentally regulated, even if their expression followed a different pattern. Utrophin was found since very early stages of developm...

journal_title：Mechanisms of ageing and development

authors： Sogos V,Curto M,Reali C,Gremo F

更新日期：2002-03-15 00:00:00

abstract：:In adult rats 3, 6 and 9 months post-orchidectomy performed at the age of 30 days the thymus weight, thymocyte yield and relative proportions of thymocyte subsets (delineated by expression of CD4/CD8 molecules and TCRalphabeta) were analyzed in order to elucidate a putative role of male gonadal hormones in the shaping...

journal_title：Mechanisms of ageing and development

authors： Leposavic G,Pejcić-Karapetrović B,Kosec D

更新日期：2002-02-01 00:00:00

abstract：:To determine the effects of prolonged hypoxia and hypoxia-reoxygenation in senescent blood vessels, isolated aortic rings from 4- and 24-month-old (mo) Wistar rats were submitted to prolonged hypoxia (50 min) or hypoxia/reoxygenation (20 min/30 min) and contractile function recorded. Phenylephrine-induced contraction ...

journal_title：Mechanisms of ageing and development

authors： Besse S,Tanguy S,Boucher F,Bulteau AL,Riou B,de Leiris J,Swynghedauw B

更新日期：2002-02-01 00:00:00

abstract：:Oxidative damage to macromolecules, including lipids, has been hypothesized as a mechanism of aging. One end product of lipid peroxidation, malondialdehyde (MDA), is often quantified as a measure of oxidative damage to lipids. We used a commercial colorimetric assay for MDA (Bioxytech LPO-586, Oxis International, Port...

journal_title：Mechanisms of ageing and development

authors： Gerhard GS,Kaufmann EJ,Wang X,Erikson KM,Abraham J,Grundy M,Beard JL,Chorney MJ

更新日期：2002-01-01 00:00:00

abstract：:It strikes me that among our relatively small community of gerontologists concerned with genetic approaches to our science, there is somewhat of a dichotomization. On the one hand, there are those of us, like myself, who tend to be dour 'complificationists'. Journalists talk to us, but are usually disappointed by the ...

journal_title：Mechanisms of ageing and development

authors： Martin GM

更新日期：2002-01-01 00:00:00

abstract：:There are multiple lines of evidence showing that oxidative stress and aberrant mitogenic signaling play an important role in the pathogenesis of Alzheimer disease. However, the chronological relationship between these and other events associated with disease pathogenesis is not known. Given the important role that mi...

journal_title：Mechanisms of ageing and development

authors： Zhu X,Castellani RJ,Takeda A,Nunomura A,Atwood CS,Perry G,Smith MA

更新日期：2001-12-01 00:00:00

abstract：:The observations of the loss of cholinergic function in neocortex and hippocampus in Alzheimer's disease (AD) developed the hypothesis that replacement of cholinergic function may be of therapeutic benefit to AD patients. The different approaches proposed or tested included intervention with acetylcholine (ACh) precur...

journal_title：Mechanisms of ageing and development

authors： Amenta F,Parnetti L,Gallai V,Wallin A

更新日期：2001-11-01 00:00:00

abstract：:We examined physiological changes in CD5(+) B lymphocytes in mice associated with aging (from 1 or 5 to 50 weeks of age). The most predominant populations of lymphocytes among these mice were mainly CD5(-) B cells in the spleen and peritoneal cavity, and T cells in the thymus. However, in the spleen, CD5(+) B cells in...

journal_title：Mechanisms of ageing and development

authors： Watanabe K,Watanabe M,Maruoka H,Amino N,Iwatani Y

更新日期：2001-10-01 00:00:00

abstract：:T cell responses are altered in the aged in a manner usually interpreted as detrimental to host defences against infectious agents and possibly also against cancer. T cell dysregulation may be caused by any or a combination of stem cell deficits, compromised T cell differentiation, inefficient antigen processing and p...

journal_title：Mechanisms of ageing and development

authors： Pawelec G,Hirokawa K,Fülöp T

更新日期：2001-09-30 00:00:00

abstract：:There is an alteration of the immune response in aging that leads to the increased incidence of infections, cancers and autoimmune disorders. The aim of the present study was to investigate whether there exists changes in signal transduction under the IL-2 receptor stimulation and the role of plasma membrane cholester...

journal_title：Mechanisms of ageing and development

authors： Fülöp T Jr,Douziech N,Goulet AC,Desgeorges S,Linteau A,Lacombe G,Dupuis G

更新日期：2001-09-15 00:00:00

abstract：:Neutral endopeptidase 24.11 (NEP) inhibitors prevent breakdown of atrial natriuretic peptide (ANP), and may be useful therapeutically, in sodium overload states as often occurs in the aged. However, age-dependent changes in ANP/NEP may limit the activity of these agents in the elderly. To investigate this we conducted...

journal_title：Mechanisms of ageing and development

authors： Greenfeld Z,Engels K,Samsell L,Baylis C

更新日期：2001-09-01 00:00:00

abstract：:T cells in vivo have been shown to accumulate DNA damage with age. To investigate the effects of DNA damage on T cell biology we have utilised an in vitro human CD4+ T cell clone model. Levels and types of DNA damage were determined in 11 independent T cell clones as a function of their in vitro lifespan. Increased le...

journal_title：Mechanisms of ageing and development

authors： Hyland P,Barnett C,Pawelec G,Barnett Y

更新日期：2001-08-01 00:00:00

abstract：:With recent sequencing of the genome and development of high-density array technology, it is now possible to assess global gene expression in cells/tissues by a technique that is sensitive, quantitative, and rapid. Gene expression array technology is extremely useful in studying a complex, multigenetic process, such a...

journal_title：Mechanisms of ageing and development

authors： Han E,Hilsenbeck SG

更新日期：2001-07-31 00:00:00

abstract：:Protein oxidation, one of a number of brain biomarkers of oxidative stress, is increased in several age-related neurodegenerative disorders or animal models thereof, including Alzheimer's disease, Huntington's disease, prion disorders, such as Creutzfeld-Jakob disease, and alpha-synuclein disorders, such as Parkinson'...

journal_title：Mechanisms of ageing and development

authors： Butterfield DA,Kanski J

更新日期：2001-07-15 00:00:00

abstract：:The paper of Kitani cited in the title has raised an apparent contradiction regarding the validity of certain aspects of the membrane hypothesis of aging (MHA). He collected data showing that a number of detoxifying liver enzyme activities, although decline with age in male Fischer 344 rats, remain at an unchanged lev...

journal_title：Mechanisms of ageing and development

authors： Zs-Nagy I

更新日期：2001-06-01 00:00:00

abstract：:Cell proliferation, cell injury and aging are connected with changes in the cell membrane structure. Apparently these changes activate, in mammalian as well as in plant cells, lipases which liberate polyunsaturated fatty acids (PUFAs). PUFAs are the substrates for lipoxygenases which convert them to corresponding hydr...

journal_title：Mechanisms of ageing and development

authors： Spiteller G

更新日期：2001-05-31 00:00:00

abstract：:In order to gain a better understanding of tissue plasticity with aging, we investigated the adaptive responses of young and adult animals to both 7 and 28 days of hypobaric hypoxia. Senescence is associated with a decreased tolerance to hypoxia that may be related to an age-associated decline in glucose transporter s...

journal_title：Mechanisms of ageing and development

authors： Dill RP,Chadan SG,Li C,Parkhouse WS

更新日期：2001-05-15 00:00:00

abstract：:In the present work, we investigated whether IGF-1 regulates the transcription of the genes encoding the L-type Ca2+ channel (DHPR) channel and RyR1 in young adult and senescent mice. To this end, a transgenic mouse model overexpressing IGF-1 exclusively in skeletal muscle (S1S2) was studied at different ages and the ...

journal_title：Mechanisms of ageing and development

authors： Zheng Z,Messi ML,Delbono O

更新日期：2001-04-15 00:00:00

abstract：:The quantification of plasmatic HLA class-I molecules (sHLA-I) was realized by a sandwich ELISA using a monomorphic mAb (W6/32). sHLA-I concentration is significantly increased in the elderly group (>50 years, 0.429+/-0.301 microg ml(-1)) as compared to the young group (<50 years, 0.126+/-0.085 microg ml(-1)). The var...

journal_title：Mechanisms of ageing and development

authors： Le Morvan C,Cogné M,Drouet M

更新日期：2001-03-01 00:00:00

abstract：:Susceptibility for Friend leukemia virus (FLV)-induced leukemogenesis was examined in the C3H/He (C3H)-->C57BL/6 (B6) radiation bone marrow chimeras of various age groups, and the effect of aging of host mice on the susceptibility was determined. The bone marrow chimera system provided the various age of FLV-resistant...

journal_title：Mechanisms of ageing and development

authors： Yamaguchi S,Kitagawa M,Inoue M,Tejima Y,Kimura M,Aizawa S,Utsuyama M,Hirokawa K

更新日期：2001-02-01 00:00:00

abstract：:This review addresses a novel facet of human T cell biology that constitutes a fundamental problem for long-term maintenance of immunological memory against viruses. The finite proliferative capacity of human T lymphocytes is sufficiently great to accommodate the waves of clonal expansion associated with primary and e...

journal_title：Mechanisms of ageing and development

authors： Effros RB

更新日期：2000-12-20 00:00:00

abstract：:We have developed a relatively rapid, safe and simple method for the quantification of sjTREC levels in samples of peripheral blood. The assay uses an image analysis package to measure the brightness of PCR product bands on an image of the standard agarose gel. Comparison of the brightness of the band with that obtain...

journal_title：Mechanisms of ageing and development

authors： Aspinall R,Pido J,Andrew D

更新日期：2000-12-20 00:00:00

abstract：:Our previous results indicated that glutathione (GSH) and/or cysteine (Cys) deficiency occurs in many aging tissues and also after acetaminophen (APAP) administration. The aim of this study was to investigate whether GSH monoethyl ester (GSH-OEt) can correct these deficiencies. Mice of different ages (3-31 months) thr...

journal_title：Mechanisms of ageing and development

authors： Chen TS,Richie JP,Nagasawa HT,Lang CA

更新日期：2000-12-01 00:00:00